April 4, 2017

Download Acute Myelogenous Leukemia in Childhood: Implications of by Privatdozentin Dr. med. Ursula Creutzig (auth.), PDF

By Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)

The result of remedy for adolescence acute myelogenous leukemia (AML) have better significantly over the last ten years. This development was once established through the 2 consecutive multicenter reports, AML-BFM-78 and -83, within which nearly exact prolonged multi drug regimes of che­ motherapy have been administered for 8 weeks and up via years upkeep. the most distinction within the moment examine used to be the addition of an eight-day extensive in­ duction direction. because of this new aspect, the relapse fee was once decreased considerably. one other results of the BFM-83 research used to be the definition of 2 threat teams at the foundation of standardized remedy, which has result in a risk-adapted therapy process within the 3rd ongoing trial, AML-BFM- 87. This development used to be in simple terms attainable because of the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and particularly the workers on the hospitals and reference laboratories. therefore, we wish to thank every body who has been considering those stories and wish that they are going to be additional inspired to enhance remedy options for AML in kids. The coordination, enforcement, and analyses of the stud­ ies should not have been attainable with out the monetary sup­ port of the Federal Ministry for examine and expertise of the FRG. we're thankful for the beneficiant contributions helping this publication from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 creation . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

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Additional resources for Acute Myelogenous Leukemia in Childhood: Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies

Sample text

Gingiva Lymphoma Intestines Muscular system Pericard Lungs Testes Testes and skin All organs Kidney Bone Orbita AML-BFM-83 8 4 3 1 3 2 4 1 13 7 4 2 2 2 2 1 t 1 1 2 to} ! 3 0 .... Il! 0 n. 0 Il! n. 0+---~--~--~--~~--L---4----L--~6 100 a 1000 TOTAL GROUP 10000 (N = 333 ) 100000 1·10, LEUKOCYTES Fig. 5 a-d. Distribution of leukocyte counts in AML-BFM-78 and AMIFBFM-83. B '"a. 6 :::::1:::1:::::[::-:1 . <~. . . . 1....................... /. ! ! :::::::. .. 10 6 b __ AML-78 ......... 3 o t- H ~ a.

B .... --~~~,-~~~~,-~~-r 0 2 3 - - AML-BFM 78 ( N ........... AML-BFM 83 ( N - 4 5 29 31 6 7 B 9 10 YEARS 15 IN CCR ) 23 IN CCR ) Fig. 14. a Probability of EFS duration in patients with FAB Ml in AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M3. Out of a total of 11 patients with acute promyelocytic leuke- mia, two suffered ED from intracranial hemorrhage, one from ulcer bleeding and one from sepsis. Of the two children who died in CCR, one died after six weeks from the sequelae of anthracycline-induced cardiotoxicity, the other from undetected tuberculosis after eight months.

B Same for EFI duration FAB M7. Out of three patients with acute megakaryoblastic leukemia in AML-BFM-83, one was in CCR for 28 months; the other two died within five months after achieving partial remission or suffering early relapse. Results 46 >..... l. -~---r- o FAB 6 ( N 2 = 10; 3 4 5 YEARS 4 IN CCR ) Fig. 18. Probability of EFS duration in patients with FAB M6. 5 Risk Factor Analysis of Pretherapeutic and Response-Kinetic Parameters The following analysis refers to protocol patients. Risk factors predicting failure to achieve remission as well as relapse are analyzed first; analysis of the risk factors predicting ED is carried out separately (Sect.

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