By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the previous years have visible speedy development within the box of adenovirus learn. furthermore, adenoviruses have attracted significant curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity offers with the immune procedure, oncogenesis and gene treatment.
Read Online or Download Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy PDF
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Extra info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy
Therefore, these E3 functions are proposed to contribute profoundly to immune evasion and to the establishment of persistent infections in vivo (Mahr and Gooding 1999; Wold et al. 1999; Burgert and Blusch 2000; Burgert et al. 2002). Interestingly, most of these immunosubversive E3 functions exploit the membranous organelles of the secretory pathway and the endosomai/lysosomal system, which are not essential for replication in vitro. Collectively, E3 proteins target important host recognition molecules that are removed from the cell surface, either by preventing expression of newly synthesized molecules on the cell surface or by rerouting them into lysosomes.
The size/name of common ORFs is only given once. Gaps between ORFs have been artificially introduced to align homologous ORFs. The E3 promoter overlaps with part of the pVIII ORF, which is not an E3 gene signal-anchor domain (type Ib transmembrane proteins). As the E3 region is not required for Ad replication in vitro, but is present in all human Ads, it is thought to playa crucial role for efficient virus propagation in the face of the host immune response in vivo and thus for Ad pathogenesis and persistence.
Windheim et al. 36 Secretory pathway Endocytic pathway Fig. 2 Trafficking in the secretory and endocytic pathway. Export from the ER to the ERGIC occurs via COPII-coated vesicles, whereas transport from the ERGIC to the cis-Golgi, between the Golgi cisternae and retrograde to the ER is mediated by COPI-coated vesicles. From the TGN, proteins can be transported (1) to the plasma membrane via secretory vesicles or (2) to early (EE) or late (LE) endosomes by clathrin-coated vesicles involving the clathrin adaptor proteins AP-l and AP-3 and the GGAs.
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