By Eric J. Toone
Advances in Enzymology and comparable parts of Molecular Biology covers the advances in enzymology, explaining the habit of enzymes and the way they are often applied to strengthen novel medicinal drugs, synthesize recognized and novel compounds, and comprehend evolutionary processes.Content:
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Additional info for Advances in Enzymology: And Related Areas of Molecular Biology, Volume 75
38 STEVEN A. BENNER, SLIM O. SASSI, AND ERIC A. GAUCHER RNases proved to present several opportunities for biological interpretation and discovery. As digestive enzymes, pancreatic RNases lie at one interface between their host organisms and their changing environments, and are expected to evolve with the environment. Not all mammals, however, have large amounts of pancreatic RNase. In fact, RNase is abundant in the digestive systems primarily in ruminants (which include the oxen, antelopes, and other bovids, together with the sheep, the deer, the giraffe, okapi, and pronghorn) and certain other special groups of other herbivores (Barnard, 1969).
To the extent that extinctions have removed information from the biosphere, it may be impossible to find an extant organism that branches from the tree at a strategic point useful to resolve an ambiguity in ancestral reconstruction. Of course, it is always possible that collecting additional sequences may not resolve ambiguities. Indeed, additional sequences might create new MOLECULAR PALEOSCIENCE: SYSTEMS BIOLOGY FROM THE PAST 33 ambiguities, especially when long branches are being articulated.
This is not bad, as it means that additional sequences have discovered ambiguities that exist but were not revealed by the previous, smaller data set. Although it is obvious, a general rule is worth stating: The more sequences in the data set, and the more broadly the relevant history is sampled, the more reliable the reconstructed ancestral sequences will be. The biodiversity represented in the microbial world is only beginning to be explored, of course. This suggests that sequencing of the type that Venter performed will add data and will make paleomolecular reconstructions increasingly reliable over the coming decades.
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